Get a copy of the CFM Performance curve for your DC if you can find it. You can use Bill Pentz spreadsheet or your own calculations and calculate the CFM at the longest run on each branch. Make sure you have sufficient air velocity in the verticals and horizontals to move the dust and chips. Bill Pentz website has this info. The largest pipe you can calculate and maintain the velocity needed is your best bet. My first installation in my double garage with short runs was 4" PVC and it worked great. My new shop has a longest run of about 50 feet and I used 6" spiral mains and 4" spiral drops. The big box HVAC duct has the wrong connection direction so the chips can collect at each connection and eventually block the pipe. Better with PVC or true dust collection pipe. I bought mine from Rockler. Probably paid a little more but it was very easy to purchase what I needed there. One time expense. For the drops it is important that you connect to the main with a WYE horizontal then 90 down with the drop. If you exit directly down then chips and dust will drop into the vertical pipe and build up at the gate. If you get too much build on less used machines it is possible that the DC will not be able to move it.
Michael Dilday
Suffolk, Va.