I've a new customer that wants me to cut out shapes. The trick is this is a 2'x4' sheet with several hundred printed images on the sheet and I'll be cutting out around them.
The printer is actually printing on a 4ft x 8ft sheet and then router cutting into smaller sheet. So sheets won't be able to be registered once and then lasered.
(at least I expect there to be some difference in size of sheet after routing and hence registration won't match sheet to sheet.)

Any tricks to help here?

I'm having him print some registration marks on each small sheet that I'll work to use to line up sheet, but I was hoping not to spend 5 minutes per sheet to register.