I used to think that glue, by itself, was sufficient for miters. I made jewelry boxes with mitered corners and used to just glue them. Then, one day, I dropped one and one of the corners came open. Since then, I put an FF biscuit in all my miters. Even with the biscuit, I think a corner can come loose if you drop it hard enough or enough times but it will last longer than without a biscuit.
Mike