This may be a bit controversial, but I've been riding for 40 years, and:
If you're driving a QUIET bike, prepare to defend your life in the form of dodging cars moving into your lane while you're in it, nearly every other time you ride. Doesn't matter how big the bike is either.
How my '84 Aspencade can be completely invisible to people in cars is a total mystery...
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--but it is!
But, if you're driving something akin to a LOUD straight-piped Harley, You Will Be Safer.
I've owned this '75 Sporty since 1992--
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and I can't remember one time that a car ever changed lanes into me. The ONLY close call I've ever had on this bike was some lady who almost ran into the back of me at the bottom of a cloverleaf off-ramp. But I did see her coming in the mirrors...
That's my 2c on one way to stay safe
Aside from that, keep eagle eyes on everyone around you at all times, and always leave yourself an OUT.
Enjoy!
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