off the top of my head, and i haven't had a need to build doors this large mind you, there are two main engineering issues to consider. the hinges being strong enough to hold up over time, and the rails being strong enough to resist flex.
general properties of doors as they pertain to this example...
as for the design of the door and flex...if you plan to make them out of solid wood in the traditional way, i would have at least 5 rails. the typical molded profile on a door is 1/2" deep, so subtracting 1/2 from each side, what's left is the width of the tenon and the panel groove. so a 2" door will leave you a 1" wide tenon, a 1 3/4" door will leave you a 3/4" tenon. the more rails you have, the more mortise joints you have, thus the more the door will resist flex.
the general rule of thumb is for tenons to go halfway through your stiles. i see no need to deviate from that here.
the bottom rail should be roughly twice the width of the other rails, on that i also see no need to deviate from that general rule. you want it to be bottom heavy, and stronger at the bottom, since the generally accepted height for the knob or handle is 3 feet, which is biased toward the bottom.
a split panel design would add additional strength to the rails, by providing an additional mortise joint in each rail that will further resist flex. see this old pocket door as an example, which is the closest thing to what you're attempting as far as extreme (and larger, even) dimensions go...
http://s93883215.onlinehome.us/adamj...041-783695.jpg
as for the hinges, if you use typical mortise hinges, i'd do three 6" hinges on each door. this will be quite heavy. going by what i've done before, on a 2" thick exterior door 80x36, using old growth yellow pine which is roughly 3 pounds per square foot, three 5" hinges is borderline strong enough. your doors being larger, more is called for. if you go with strap hinges or gate hinges or other such things, i'm not really sure there, like i said i don't build those types of thing so don't have alot of experience with such hinges. you will also need additional reinforcement between the frame and the studs to keep the frame stable. i'd splice a horizontal support in behind each hinge between the first and second studs in addition to the top.
if these will be exposed to the elements, i'd use flat panels, no end grain exposure on the panels that way. on an interior door you can use plywood panels to add some extra strength if you go with flat panels, but i wouldn't use plywood on an outside door, i'm sure you've seen what happens to plywood left in the rain.
with all of that in mind, i'd do something like this...the dimensions on the below are 2" thick, 5" wide rails/stiles, a 10" bottom rail, and 10" wide panels. of course you can dress up the glass area however you like, or eliminate it altogether even, that's personal preference. the framing example is obviously not the proper scale, but assuming you had a rough opening for this set of doors to go into, the below is how i'd frame it to make sure you had the support for the weight of the doors in question. i personally prefer 3" deck screws rather than nails for such framing, but framing nails would be fine as well.
and this is all probably overkill, i'm no structural engineer (although i'm sure there are probably a few here who can provide more accurate minimums...), as far as the necessary hinges and framing methods, i just go by what i've seen stand up for over 100 years and duplicate that plus a little more for good measure
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